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KMID : 0379119830110030115
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Korean Journal of Mycology
1983 Volume.11 No. 3 p.115 ~ p.119
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Steroid Modification with Aspergillus phoenicis
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Abstract
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The bioconversion of progesterone by Aspergillus phoenicis has been studied. The metabolism in the conditions of experiment gave 11α-hydroxyprogesterone as main product. The concentration of 11α-hydroxyprogesterone increased monotonically and leveled off after 40 hours of incubation. Addition of glucose into the medium reduced considerably the time for attaining limiting concentration of 11α-hydroxyprogesterone. The increase in initial progesterone concentration did not affected the percentage of conversion nor the time required for termination of the reaction. But it could not be represented as first order reaction with respect to progesterone concentration. The degree of inhibition of enzymes by organic solvents depended upon the concentration of solvents. At low solvent concentration, acetone proved to yield the highest conversion.
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